Inhaled, Systemic Steroids Linked to Changes in Brain Structure

New research links the use of glucocorticoids with changes in white matter microstructure — which may explain the development of anxiety, depression, and other neuropsychiatric side effects related to these drugs, investigators say. Results from a cross-sectional study showed that use of both systemic and inhaled glucocorticoids was associated with widespread reductions in fractional anisotropy … Read more

Stable, Long-term Opioid Therapy Safer Than Tapering?

Discontinuing Stable, Long-TERM OPIOIID Therapy May Not BE NECESAY FOR PATIENTS who show no Signs of Misuse ― and IT COUL Even Be Safer Than Tapering Or Aburt Discontinism, New Research Suggests. Investigators Analyzed Data for Almost 200,000 Patients who did not have signs of OPIOOID USE DISEORDER (Oud) and Were Receiving Opioid Treatment. The … Read more

Best Meds for Insomnia Identified?

Two drugs have emerged as the optimal medications for treating insomnia based on the “best-available evidence,” but there are caveats. In a comprehensive comparative-effectiveness analysis, lemborexant and eszopiclone showed the best efficacy, acceptability, and tolerability for acute and long-term insomnia treatment. However, eszopiclone may cause substantial side effects — and safety data on lemborexant were … Read more

Best Strategy to Prevent Schizophrenia Relapse Identified?

A large meta-analysis sheds light on the best antipsychotic maintenance strategy to prevent relapse in clinically-stable schizophrenia — with some unexpected results that have potential implications for changes to current guidelines. Consistent with the researchers’ hypothesis, continuing antipsychotic treatment at the standard dose, switching to another antipsychotic, and reducing the dose were all significantly more … Read more

Opioid Use in the Elderly a Dementia Risk Factor?

Opioid use in the elderly is associated with an almost 40% increased risk of dementia, in new findings that suggest exposure to these drugs may be another modifiable risk factor for dementia. “Clinicians and others may want to consider that opioid exposure in those aged 75-80 increases dementia risk, and to balance the potential benefits … Read more

Cannabis on Par With Opioids for Pain Relief, Study Suggests

Cannabis-based products may control chronic pain as effectively as opioids, but adverse effects are common, and long-term safety remains unknown, according to a new study. Several other systematic reviews have recently evaluated cannabinoids for treating chronic pain, but the new study’s methodology was “distinct” in “important ways,” leading to “conclusions that differ from other reviews,” … Read more

High-Dose Antipsychotics Effective in Refractory Schizophrenia

NEW ORLEANS – Patients with severe schizophrenia who fail to respond to treatment with standard doses of second-generation antipsychotics show significant improvement with – and tolerance of – higher maintenance doses of the drugs, new research shows. Dr Juan Jose Fernandez-Miranda The use of [higher doses of] long-acting injectable second-generation antipsychotics shows improvement not only … Read more

Faster Response to IV vs Intranasal Ketamine in Depression

NEW ORLEANS – New research reveals that patients with treatment-resistant depression who were treated with repeated intravenous differences ketamine show no significant in achieving response or remission, compared with those receiving the intranasal formulation of the drug, esketamine – although fewer treatments appear necessary with the intravenous formulation. Dr Balwinder Singh “This is one of … Read more

A Little-Known Option for Depression

Standard therapies for depression are antidepressants and psychotherapy. In particularly severe cases, electroconvulsive therapy (ECT) or vagus nerve stimulation (VNS) may also be indicated. VNS is an approved, effective, well-tolerated, long-term therapy for chronic and therapy-resistant depression, write Christine Reif-Leonhardt, MD, and her team of researchers from the University Hospital Frankfurt am Main, Germany, in … Read more

Study Provides New Data on Isotretinoin and Psychiatric Effects

The use of isotretinoin to treat acne was not associated with an increase in adverse neuropsychiatric outcomes, compared with the use of oral antibiotics, in a large retrospective cohort study published in the British Journal of Dermatology. Although severe neuropsychiatric effects associated with isotretinoin therapy in patients with acne have been reported, “the evidence base…is … Read more