Novel Alzheimer’s Treatment Disappoints in Twin Phase 3 Trials

The investigational anti-amyloid monoclonal antibody gantenerumab (Genentech/Roche) showed no clear benefit for patients with early Alzheimer’s disease (AD) in the phase 3 GRADUATE I and II trials, the company has announced. Although gantenerumab was well tolerated, including during subcutaneous administration, it failed to meet the primary endpoint of slowing clinical decline. Still, the Alzheimer’s Association … Read more

Traffic-Related Pollutant Tied to Increased Dementia Risk

Exposure to a traffic-related air pollutant significantly increases risk for dementia, new research suggests. Results from a meta-analysis, which included a total of more than 90 million people, showed risk for dementia increased 3% for every 1 microgram per cubic meter rise in fine particulate matter (PM2.5) exposure. Particulate matter is a mixture of solid … Read more

Dementia Prevalence Study Reveals Inequities

Dementia and mild cognitive impairment (MCI) disproportionately affect Black and Hispanic individuals, as well as people with less education, based on new US data from The Health and Retirement Study (HRS). Dr Jennifer Manly These inequities likely stem from structural racism and income inequality, necessitating a multifaceted response at an institutional level, according to lead … Read more

Common Menopausal Symptoms Tied to Impaired Brain Health

Hot flashes and night sweats in middle-aged women are associated with greater white matter hyperintensity volume (WMHV), a marker of small vessel disease in the brain, in new findings that call into question the idea that these symptoms are benign. These new findings challenge the long-held belief that the most common menopausal vasomotor symptoms (VMS) … Read more

Novel Approach to TMS May Slow Cognitive Decline in Alzheimer’s

A novel approach to repetitive transcranial magnetic stimulation (rTMS) that targets the precuneus appears to slow the progression of cognitive and functional decline in patients with Alzheimer’s disease (AD), new research suggests. Results from 6-month, phase 2, randomized, double-blind trial show that patients with AD who received rTMS over the 24-week trial maintained stable scores … Read more

Patients With Schizophrenia Twice as Likely to Develop Dementia?

Patients with psychotic disorders such as schizophrenia are more than twice as likely as those without a psychotic disorder to eventually develop dementia, new research suggests. Results from a review and meta-analysis of almost 13 million total participants from nine countries showed that, across multiple different psychotic disorders, there was a 2.5-fold higher risk of … Read more

‘Amazing’ Phase 3 Results for Novel Schizophrenia Combo Drug

VIENNA — The investigational agent xanomeline-trospium (KarXT, Karuna Therapeutics) achieves significant and clinically meaningful improvements in schizophrenia symptom scores without causing problematic adverse effects, new research suggests. Results from the phase 3 EMERGENT-2 trial, which included more than 250 patients with schizophrenia, showed that those who received xanomeline-trospium for 5 weeks achieved a significant reduction … Read more

No Effect of Diet on Dementia Risk?

Contrary to some prior studies, new research suggests that a healthy diet, including the Mediterranean diet, does not reduce dementia risk. After adjusting for relevant demographic and other lifestyle measures, there was no association between adherence to healthy dietary advice or the Mediterranean diet on the future risk of dementia or beta-amyloid (Aβ) accumulation. “While … Read more

One Type of Older Diabetes Drug Cuts Dementia Risk, Another Ups It

Thiazolidinediones (TZDs), such as pioglitazone, appear to be protective against dementia whereas sulfonylureas appear to increase the risk, a new observational study in patients with type 2 diabetes suggests. The data, obtained from nationwide electronic medical from the US Veterans Affairs Administration, yielded a 22% lower risk of dementia with TZD monotherapy and a 12% … Read more

Three Groups at Increased Suicide Risk After Dementia Diagnosis

Three subgroups of patients are at increased risk for suicide following a diagnosis of dementia ― a finding that paves the way for more targeted suicide risk assessment and intervention, new research suggests. In a large population-based, case-control study, results showed an increased risk for suicide among those with younger-onset dementia, defined as being diagnosed … Read more