alzheimer’s

Higher scores regarding seven modifiable cardiovascular and brain health factors are linked to lower dementia risk in middle-aged individuals at high genetic risk for the disorder, new research shows. Investigators found that individuals with the APOE ε4 variant who scored high on the American Heart Association’s (AHA ‘s) Life’s Simple 7 (LS7) modifiable health factors … Read more

Vascular risk factors for dementia vary with age, new research suggests. New data from the Framingham Heart Study show that high systolic blood pressure (SBP) and diabetes are the most important vascular risk factors for increased 10-year incident dementia at age 55, whereas heart disease was identified as a more important risk factor for dementia … Read more

The study covered in this summary was published in medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways The clinical value of biologic criteria ― global amyloid burden (A), composite of temporal region of tau PET uptake (T), and presence of neurodegeneration (N) ― was confirmed to predict cognitive impairment in … Read more

The combination of hearing loss and vision loss is linked to an eightfold increased risk of cognitive impairment, new research shows. Investigators analyzed data on more than 5 million US seniors. Adjusted results show that participants with hearing impairment alone had more than twice the odds of also having cognitive impairment, while those with vision … Read more

For healthy middle-aged and older adults, adding cranberries to the diet may help improve memory and brain function, in addition to lowering LDL cholesterol, new research suggests. Results from a randomized, placebo-controlled trial of adults aged 50-80 years showed that consuming freeze-dried cranberry extract, which is equal to one cup of fresh cranberries, for 12 … Read more

Individuals diagnosed with young-onset dementia (YOD) have an alarmingly high risk of serious injury because of motor vehicle accidents — both as pedestrians and drivers. Results from a longitudinal, registry-based cohort study showed that compared with the general population, YOD patients had an almost twofold increased risk of MVA-related injury. Dr Jiun-Yi Wang “These findings … Read more

Higher levels of specific carotenoid antioxidants in blood may help guard against age-related dementia, new research suggests. Investigators found that individuals with the highest serum levels of lutein+zeaxanthin and beta-cryptoxanthin at baseline were less likely to have dementia decades later than their peers with lower levels of these antioxidants. Lutein and zeaxanthin are found in … Read more

The study covered in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Higher expression and upregulation of fatty acid pathways and the phospholipids associated phosphatidylethanolamine (PE) and diacylglycerol (DAG) were with smaller whole-brain volumes and may be linked with neurodegeneration and Alzheimer’s disease (AD). Overall, … Read more