A ‘Setback’ for Anti-inflammatory Treatment in Depression

The broad-spectrum antibiotic minocycline (multiple brands) is not effective when added to standard antidepressant therapy, the largest randomized controlled trial of minocycline in treatment-resistant depression (TRD) shows. In the MinoTRD trial, 6 weeks of minocycline 200 mg daily added to stable antidepressant therapy did not show a statistically significant advantage over placebo on the overall … Read more