Schizophrenia, Postmodernism: A Philosophical Treatment Exercise

Schizophrenia is defined as having episodes of psychosis: periods of time when one suffers from delusions, hallucinations, disorganized behaviors, disorganized speech, and negative symptoms. The concept of schizophrenia can be simplified as a detachment from reality. Patients who struggle with this illness frame their perceptions with a different set of rules and beliefs than the … Read more

Baseline Neuromotor Abnormalities Persist in Schizophrenia

Baseline dyskinesia and neurological soft signs (NSS) predicted the disease process of schizophrenia over a 21-year follow-up period, based on data from 243 adult patients. Neuromotor abnormalities in psychotic disorders have long been ignored as side effects of antipsychotic drugs, but they are gaining new attention as a component of the disease process, with implications … Read more

Clozapine Best Choice for Reducing SUD Risk in Schizophrenia?

Clozapine or antipsychotic polytherapy appear to be the best approach in reducing the risk for a substance use disorder (SUD) in adults with schizophrenia and for preventing relapse in patients with both diagnoses, results of a real-world study show. “Our findings are in line with a recent meta-analysis showing superior efficacy of clozapine in schizophrenia … Read more

LAIAs More Effective Than Oral Antipsychotics for Schizophrenia

For patients with schizophrenia, long-acting injectable antipsychotics (LAIAs) are associated with a lower risk than oral antipsychotics (OAs) for disease relapse and hospitalization ― and they carry no increased risk for adverse events, new research shows. Investigators analyzed data for more than 70,000 patients with schizophrenia and found that, compared with OAs, LAIAs were associated … Read more

Dermatologists Want Training in Antipsychotic Prescribing for DI

GLASGOW — Dermatologists do not feel confident in independently prescribing antipsychotic medications for patients with delusional infestation, shows a UK survey that also indicated there is a clear demand for training in prescribing these drugs. Delusional infestation is a rare disorder characterized by an individual’s belief that his or her skin, body, or immediate environment … Read more

Best Strategy to Prevent Schizophrenia Relapse Identified?

A large meta-analysis sheds light on the best antipsychotic maintenance strategy to prevent relapse in clinically-stable schizophrenia — with some unexpected results that have potential implications for changes to current guidelines. Consistent with the researchers’ hypothesis, continuing antipsychotic treatment at the standard dose, switching to another antipsychotic, and reducing the dose were all significantly more … Read more

Lower-Dose Antipsychotics Benefit Patients with Schizophrenia

NEW ORLEANS — Patients with treatment-refractory schizophrenia in a long-term forensic facility showed significant stability following reduced doses of long-acting injectable antipsychotics, a study revealed. Dr Mujeeb Shad “There is an argument by some experts in the field that state hospital populations represent a different set of patients who require higher antipsychotic dosages, with no … Read more

High-Dose Antipsychotics Effective in Refractory Schizophrenia

NEW ORLEANS – Patients with severe schizophrenia who fail to respond to treatment with standard doses of second-generation antipsychotics show significant improvement with – and tolerance of – higher maintenance doses of the drugs, new research shows. Dr Juan Jose Fernandez-Miranda The use of [higher doses of] long-acting injectable second-generation antipsychotics shows improvement not only … Read more

Antipsychotic Tied to Weight Gain, Higher Cholesterol

Increases in use of the antipsychotic risperidone (Risperdal) are associated with small dose-related increases in both weight and blood cholesterol levels, new research suggests. Investigators analyzed 1-year data for more than 400 patients who were taking risperidone and/or its metabolite paliperidone (Invega). Results showed increments of 1 mg of risperidone-equivalent doses were associated with an … Read more

Early Metformin Minimizes Antipsychotic-Induced Weight Gain

MAR DEL PLATA, Argentina ― Psychiatrists should prescribe metformin early to patients who experience rapid weight gain after they begin taking antipsychotic drugs, according to a new evidence-based Irish guideline for the management of this common complication in adults with psychoses who are taking medications. The document was discussed during one of the sessions of … Read more