MDD Tied to Childhood Trauma Is Treatable

Despite a higher symptom burden, patients with major depressive disorder (MDD) and a history of childhood trauma (CT) can achieve significant recovery following treatment with a combination of pharmacotherapy and psychotherapy, new research suggests. Results from a meta-analysis of 29 studies from 1966 to 2019, which included almost 7000 adults with MDD, showed that more … Read more

Timing of Food Intake a Strategy for Treating Mood Disorders?

Shift workers who confine their eating to the daytime may experience fewer mood symptoms compared to those who eat both day and night, new research suggests. Investigators at Brigham and Women’s Hospital, Boston, Massachusetts, created a simulated nightwork schedule for 19 individuals in a laboratory setting. Participants then engaged in two different meal timing models … Read more

Acupuncture Eases Anxiety in Parkinson’s Patients

Acupuncture is an effective treatment for anxiety in patients with Parkinson’s disease (PD), results of a randomized controlled trial show. Both sham and real acupuncture eased PD-related anxiety at the end of 8-week treatment, but only real acupuncture had an enduring effect at 2 months after treatment ended. The early effect with sham acupuncture in … Read more

Toward a New Open-Door Model for Psychiatric Wards

If isolated, patients with mental disorders may end up having higher levels of social impairment. This has led several hospitals in Spain to set up open-door departments that are more accessible. The purpose of the open-door model is to help remove the stigma from individuals who need to be admitted to a psychiatric ward because … Read more

Ketamine Linked to Reduced Suicidal Thoughts, Depression, Anxiety

Ketamine infusions can help reduce symptoms of suicidal ideation, depression, and anxiety in patients with treatment-resistant depression (TRD), new research suggests. Results from a retrospective chart review analysis, which included more than 400 participants with TRD, illustrated that ketamine is a safe and rapid treatment in a real-world patient population, lead author Patrick A. Oliver, … Read more

‘The Kids Are Not Alright’

A new report shines a light on the toll the pandemic and other stressors have taken on the mental health of US children and adolescents over the last 6 years. The report shows a dramatic increase in use of acute care services for depression, anxiety, and other mental health conditions, especially among teens and preteens. … Read more

How Nature Nurtures the Brain: New Imaging Data

Getting close to nature has a positive impact on brain regions involved in stress processing. In a study of healthy adults, researchers observed a decrease in activity in the amygdala after a 1-hour walk in the forest, but not after a stroll on a busy city street. “The results support the previously assumed positive relationship … Read more

Ketamine Promising for Rare Condition Linked to Autism

Ketamine may be an effective treatment for children with activity-dependent neuroprotective protein (ADNP) syndrome, a rare genetic condition associated with intellectual disability and autism spectrum disorder. Also known as Helsmoortel–Van Der Aa syndrome, ADNP syndrome is caused by mutations in the ADNP gene. Studies in animal models suggest that low-dose ketamine increases expression of ADNP … Read more

Mental Health Toll of COVID-19 Pandemic Varied Worldwide

People across the world have experienced elevated mental health concerns during the COVID-19 pandemic, with major differences seen across several countries and continents, according to a new report. North Americans reported more symptoms of anxiety, depression, and posttraumatic stress disorder, whereas Europeans had more insomnia and Latin Americans had more psychological distress. Anxiety and depression … Read more

Prior Psychological Distress Tied to ‘Long COVID’ Conditions

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Experiencing psychological distress prior to becoming infected with SARS-CoV-2 is tied to an increased risk for post-COVID conditions often called “long COVID,” new research suggests. In an analysis of almost 55,000 adult participants in three ongoing studies, having depression, anxiety, worry, … Read more