EEG Backs Near-Death Experience During CPR

Brain wave recordings obtained during cardiopulmonary resuscitation (CPR) offer support to near-death experiences subjectively reported by some people who survive cardiac arrest, according to a novel new study. “These recalled experiences and brain wave changes may be the first signs of the so-called ‘near-death’ experience, and we have captured them for the first time in … Read more

Major Depression Treatments Boost Brain Connectivity

VIENNA — Inpatient treatment for major depressive disorder (MDD) can lead to brain connectivity increases that are associated with degree of symptom improvement, new research suggests. In a “repeat” MRI study, adult participants with MDD had significantly lower brain connectivity compared with their healthy peers at baseline — but showed significant improvement at the 6-week … Read more

Gut Microbiota Disruption a Driver of Aggression in Schizophrenia?

Disturbances in the gut may help explain why some patients with schizophrenia are aggressive whereas others are not, new research suggests. However, at least one expert expressed concerns over the study’s conclusions. Results from a study of 50 inpatients with schizophrenia showed significantly higher pro-inflammation, pro-oxidation, and leaky gut biomarkers in those with aggression vs … Read more

First Known Opiate Biomarker Shows Fentanyl’s Effect on Brain

Fentanyl depresses breathing about 4 minutes before symptoms of distress are evident at a dose that is 1700 times lower than that needed for sedation, new research shows. This new information comes after researchers identified a unique EEG signature produced by fentanyl, the first known biomarker of an opiate’s effect on the brain. By monitoring … Read more

When Boxers Retire, Cognition and Memory Improve

Boxers and mixed martial arts (MMA) fighters can recover cognitive and memory skills after they retire from fighting, results of a longitudinal study show. Dr Aaron Ritter “What is most exciting about the findings is that it shows us brain resiliency in action,” Aaron Ritter, MD, associate staff, neuropsychiatry and behavioral neurology, Cleveland Clinic Lou … Read more

Detachment Predicts Worse Posttraumatic Outcomes

Feelings of detachment following a traumatic event are a marker of more severe psychiatric outcomes, including depression and anxiety, new research suggests. The results highlight the importance of screening for dissociation in patients who have experienced trauma, study investigator Lauren AM Lebois, PhD, director of the Dissociative Disorders and Trauma Research Program at McLean Hospital … Read more

Plasma Biomarkers Predict COVID Neurologic Complications

SAN DIEGO – Even after recovery of an acute COVID-19 infection, some patients experience extended or even long-term symptoms that can range from mild to debilitating. Some of these symptoms are neurological: headaches, brain fog, cognitive impairment, loss of taste or smell, and even cerebrovascular complications such stroke. There are even hints that COVID-19 infection … Read more

Does Suicide Risk Show Up in the Blood?

Newly identified serum biomarkers have the potential to flag patients, via blood testing, with major depressive disorder (MDD) at high risk of suicide. Investigators found patients with MDD who died by suicide had a gene expression signature in blood distinct from patients with MDDwho died by other means. The signature included genes involved in stress … Read more

Depression Biomarkers: Which Ones Matter Most?

Multiple biomarkers of depression involved in several brain circuits are altered in patients with unipolar depression. The first comprehensive meta-analysis of all biomarkers quantified to date in cerebrospinal fluid (CSF) of individuals with unipolar depression showed that several could be “clinically meaningful” because they suggest neuroimmunological alterations, disturbances in the blood–brain-barrier, hyperactivity in the hypothalamic-pituitary-adrenal … Read more

More Evidence COVID ‘Brain Fog’ Is Biologically Based

Patients with persistent cognitive impairment months after illness with mild COVID-19 have higher levels of inflammatory markers in their cerebrospinal fluid (CSF). Researchers found elevated levels of CSF immune activation and immunovascular markers in individuals with cognitive post-acute sequelae of SARS-CoV-2 infection (PASC). Patients whose cognitive symptoms developed during the acute phase of COVID-19 had … Read more