Faster Response to IV vs Intranasal Ketamine in Depression

NEW ORLEANS – New research reveals that patients with treatment-resistant depression who were treated with repeated intravenous differences ketamine show no significant in achieving response or remission, compared with those receiving the intranasal formulation of the drug, esketamine – although fewer treatments appear necessary with the intravenous formulation. Dr Balwinder Singh “This is one of … Read more

Antipsychotic Safe, Effective for Resistant Depression

Cariprazine (Vraylar) is a safe and effective adjunctive treatment for adults with major depressive disorder (MDD) who have an inadequate response to antidepressant monotherapy, new results from a phase 3 study show. Already approved by the US Food and Drug Administration (FDA) to treat adults with schizophrenia and manic, mixed, or depressive episodes of bipolar … Read more

Lithium May Lower Osteoporosis Risk in Bipolar Disorder

NEW ORLEANS — People with bipolar disorder – particularly men – show a significantly increased risk of osteoporosis, compared with the general population, but treatment with lithium appears to offer a significant protective effect against the bone disease, according to results from the largest study of its kind. Dr Soren Ostergaard “Our findings emphasize that … Read more

APA Targets Structural Racism, Offers Solutions

The negative consequences of structural racism on mental health, and opportunities for change, are the focus of a special theme issue of the American Journal of Psychiatry (AJP), released to coincide with the American Psychiatric Association (APA) Annual Meeting. The hope is this special issue will “motivate clinicians, educators, and researchers to take actions that … Read more

Disasters Abroad a Major Trigger for Mental Illness in Expats

The 2020 explosion that rocked Beirut, killing more than 200, injuring more than 7000 and causing millions of dollars in damage had a significant impact on the mental health of Lebanese expatriates, leaving many grappling with anxiety, depression, and posttraumatic stress disorder (PTSD) , results of a new survey show. The findings highlight the importance … Read more

New Insight Into How Brain Stimulation Eases Major Depression

For the first time, researchers understand what happens to the brain when patients with treatment-resistant depression receive repetitive transcranial magnetic stimulation (rTMS). Using functional magnetic resonance imaging (fMRI), they showed that rTMS induces widespread alterations in functional connectivity in brain regions involved in emotion and motor control. ‘How does rTMS work?’ is one of the … Read more

The Stigma Associated With Mental Illness and Antidepressants

The good, the bad, and the ugly. It’s easy to talk about the good, but when it comes to having real conversations about mental health, it’s sometimes an uphill battle. We see so much about mental well-being, services, and hotlines available for those in need. In fact, it’s almost expected for schools and workplaces to … Read more

Does Suicide Risk Show Up in the Blood?

Newly identified serum biomarkers have the potential to flag patients, via blood testing, with major depressive disorder (MDD) at high risk of suicide. Investigators found patients with MDD who died by suicide had a gene expression signature in blood distinct from patients with MDDwho died by other means. The signature included genes involved in stress … Read more

New Data Support Electroconvulsive Therapy for Depression

Advocates and users of electroconvulsive therapy (ECT) have received further scientific backing: a retrospective cohort study has provided further evidence that ECT can prevent suicide among severely depressed patients. The patient cohort comprised 27,231 men and 40,096 women who had been treated as inpatients. The average age was 45.1 years (range: 18-103 years), and 4982 … Read more

Cannabinoids in Medicine: Limitless Hope or Hype?

What is the role of cannabinoids as an intoxicant and in medical applications today? This was the question addressed by Dieter Braus, MD, psychiatrist and neurologist at Vitos Clinic Rheingau in Eltville, Germany, at the DGIM Congress 2022. Dampening the Dopamine System Regardless of the type of substance-dependent addiction — whether alcohol, opiates, nicotine, or … Read more