Dopamine Dysregulation a Causative Culprit in Schizophrenia?

A genetic postmortem analysis of the brains of patients with schizophrenia suggests a dysfunction of dopamine receptors in the caudate nucleus may cause the disorder. Investigators have identified a mechanism on the dopamine receptor, known as the autoreceptor, which regulates how much dopamine is released from the presynaptic neuron. Impairment of this autoreceptor leads to … Read more

Naloxone May Fail for Overdoses Tainted With ‘Tranq,’ FDA Warns

The US Food and Drug Administration (FDA) is alerting healthcare professionals about the special management required for opioid overdoses tainted with xylazine, an animal tranquilizer known on the street as tranq, tranq dope, sleep-cut, Philly dope, and zombie drug. The tranquilizer is often combined with fentanyl or heroin, or occasionally with a stimulant, said the … Read more

‘Amazing’ Phase 3 Results for Novel Schizophrenia Combo Drug

VIENNA — The investigational agent xanomeline-trospium (KarXT, Karuna Therapeutics) achieves significant and clinically meaningful improvements in schizophrenia symptom scores without causing problematic adverse effects, new research suggests. Results from the phase 3 EMERGENT-2 trial, which included more than 250 patients with schizophrenia, showed that those who received xanomeline-trospium for 5 weeks achieved a significant reduction … Read more

Why We Shouldn’t Mess With Dopamine

Google the word “dopamine” and you will learn that its nicknames are the “happy hormone” and the “pleasure molecule” and that it is among the most important chemicals in our brains. With The Guardian Branding it “the Kim Kardashian of neurotransmitters,” dopamine has become a true pop-science darling — people across the globe have attempted … Read more

Exercise for Obese Children Can Increase Brain Function

In recent years, schools cut back on arts and physical education to make way for more instructional time. All that work and no play may be making Jack and Jill, well, dull. But new research shows that exercise can make the brain sharper. The study demonstrated that a prolonged regimen of aerobic and resistance exercises … Read more

Cannabinoids in Medicine: Limitless Hope or Hype?

What is the role of cannabinoids as an intoxicant and in medical applications today? This was the question addressed by Dieter Braus, MD, psychiatrist and neurologist at Vitos Clinic Rheingau in Eltville, Germany, at the DGIM Congress 2022. Dampening the Dopamine System Regardless of the type of substance-dependent addiction — whether alcohol, opiates, nicotine, or … Read more

New Insight Into How Psychedelics Work

What causes the dramatic alterations in subjective awareness experienced during a psychedelic “trip?” A new study maps anatomical changes in specific neurotransmitter responsible systems and brain regions that may be for these effects. Investigators gathered over 6800 accounts from individuals who had taken one of 27 different psychedelic compounds. Using a machine learning strategy, they … Read more

CBD May Help People Cut Down on Their Cannabis Use

PARIS — Following the suspension of the decree that banned the sale of cannabidiol (CBD) flowers, raw cannabis is again available in France for over-the-counter sales. The “feel-good” plant is praised for its relaxing properties. The suspension of the ban, which lasted for 3 weeks, is a mixed blessing for businesses that sell CBD-based products … Read more