Unique Primary Care Model Effective for Comorbid Depression, PTSD

A unique primary care program successfully manages patients with depression and comorbid posttraumatic stress disorder (PTSD) and, if widely implemented may result in more rapid treatment and help alleviate wait times for specialty psychiatric care. Zachary Zuschlag, MD “We know there are strains on the mental healthcare system, and sometimes something as simple as getting … Read more

Death Risk Spikes With New Onset-Depression After RA Diagnosis

The development of depression after a rheumatoid arthritis diagnosis increased the risk for death “more than sixfold” when compared with having no depression at diagnosis, according to Danish researchers. Cumulative mortality at 10 years was approximately 37% in patients with comorbid RA and depression versus around 13.5% of RA patients with no depression, Jens Kristian … Read more

No Added Benefit of Adjunctive Psychotherapy in Severe Depression?

Adding psychotherapy to pharmacologic treatment does not appear to improve treatment outcomes for patients with major depression, new research suggests. Results of a cross-sectional, naturalistic, multicenter European study showed there were no significant differences in response rates between patients with major depressive disorder (MDD) who received combination treatment with psychotherapy and antidepressant medication in comparison … Read more

Genetic Testing for Best Antidepressant Accurate, Cost-Effective

Genetic testing to determine the best antidepressant for patients with major depressive disorder (MDD) has the potential to lead to an optimal drug choice on the first try and reduce healthcare costs, new research suggests. CYP2D6 and CYP2C19, from the cytochrome P450 family, are involved in the metabolism and elimination of various molecules, including medications. … Read more

Novel Drug ‘Promising’ for Concomitant Depression, Insomnia

The novel antidepressant seltorexant (Janssen Pharmaceuticals) may be beneficial for patients with concomitant major depressive disorder (MDD) and sleep disturbance, new research suggests. In a randomized, placebo-controlled, adaptive dose-finding study conducted in more than 200 patients with MDD, those with more severe insomnia at baseline had a greater improvement in depressive symptoms vs those with … Read more

Cannabis on Par With Opioids for Pain Relief, Study Suggests

Cannabis-based products may control chronic pain as effectively as opioids, but adverse effects are common, and long-term safety remains unknown, according to a new study. Several other systematic reviews have recently evaluated cannabinoids for treating chronic pain, but the new study’s methodology was “distinct” in “important ways,” leading to “conclusions that differ from other reviews,” … Read more

Psilocybin Effective Up to 12 Weeks in Severe Depression

NEW ORLEANS – A single dose of a synthetic formulation of psilocybin provides rapid improvement in treatment-resistant depression, with benefits sustained for up to 12 weeks, according to results from the largest randomized controlled study of psilocybin to date. Dr Guy Goodwin “This is easily the largest study of a psychedelic drug employing modern randomized … Read more

Antipsychotic Safe, Effective for Resistant Depression

Cariprazine (Vraylar) is a safe and effective adjunctive treatment for adults with major depressive disorder (MDD) who have an inadequate response to antidepressant monotherapy, new results from a phase 3 study show. Already approved by the US Food and Drug Administration (FDA) to treat adults with schizophrenia and manic, mixed, or depressive episodes of bipolar … Read more

The Stigma Associated With Mental Illness and Antidepressants

The good, the bad, and the ugly. It’s easy to talk about the good, but when it comes to having real conversations about mental health, it’s sometimes an uphill battle. We see so much about mental well-being, services, and hotlines available for those in need. In fact, it’s almost expected for schools and workplaces to … Read more

Do Psychotropic Meds Raise or Lower COVID Risk?

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Different psychotropic medications are associated with different risks of COVID-19 in hospitalized patients with serious mental illness, a new study suggests. Investigators found that second-generation antipsychotics were associated with a 48% lower risk of COVID-19, while valproic acid was associated with … Read more