No Spike in Overdose Deaths From Relaxed Buprenorphine Regs

Measures enacted in the early days of the COVID-19 pandemic to increase access to buprenorphine did not lead to an increase in the proportion of overdose deaths involving the drug, new research suggests. Researchers say the data add weight to the argument for permanently adopting the pandemic-era prescribing regulations for buprenorphine, a treatment for opioid … Read more

IV Ketamine Effective for Resistant Depression in Older Adults?

Dr Marie Anne Gebara The administration of IV ketamine over the course of 2 months can improve treatment resistant depression (TRD) and executive function in older adults, findings from a new pilot study suggest. Results showed nearly 50% of participants responded to ketamine and 25% achieved complete remission from TRD, as measured by scores on … Read more

Antipsychotic Use in Pregnancy: New Data

New data suggests that in general, antipsychotics are not associated with any increased risk of congenital malformations in a growing fetus, new data show. Dr Krista Huybrechts Overall, the findings suggest that antipsychotics are “not major teratogens and are therefore generally reassuring for women who require treatment with antipsychotics during pregnancy,” study investigator Krista Huybrechts, … Read more

Brodalumab Suicide Risk Similar to Other Biologics, Study Finds

An analysis of postmarketing suicide data shows that the risk of suicide associated with brodalumab use is similar to that of other biologics prescribed for psoriasis. The Food and Drug Administration approved brodalumab (Siliq) in 2017 for treatment of moderate to severe plaque psoriasis with a boxed warning for suicidal ideation and behavior and an … Read more

Triptans in Pregnancy and ADHD in Kids: New Reassuring Data

Triptan use during pregnancy does not increase the risk for attention-deficit/hyperactivity disorder (ADHD) in offspring, new research suggests. Hedvig Nordeng, PhD “The findings should satisfy women who need to take this class of drugs during pregnancy,” study author Hedvig Nordeng, PhD, professor and head of the Pharmacoepidemiology and Drug Safety Research Group at the University … Read more

Clozapine and Cancer Risk: New Data

Dr. Jari Tiihonen Long-term treatment with clozapine is associated with a small, but significant, risk of hematological malignancies in individuals with schizophrenia, new research shows. Investigators found long-term clozapine use of more than 5 years was linked to a 2.7-fold increased risk of hematological malignancies in a dose-dependent manner compared with other antipsychotics. “Our results … Read more