Ketamine Linked to Reduced Suicidal Thoughts, Depression, Anxiety

Ketamine infusions can help reduce symptoms of suicidal ideation, depression, and anxiety in patients with treatment-resistant depression (TRD), new research suggests. Results from a retrospective chart review analysis, which included more than 400 participants with TRD, illustrated that ketamine is a safe and rapid treatment in a real-world patient population, lead author Patrick A. Oliver, … Read more

Borderline Personality Disorder Raises MDD Relapse Risk After ECT

Borderline personality disorder was significantly associated with relapse after 6 months in adults with major depressive disorder who underwent electroconvulsive therapy (ECT), based on data from 109 individuals. Dr Matthieu Hein ECT has demonstrated effectiveness for treatment of unipolar and bipolar major depression, but relapses within 6 months are frequent, and potential factors affecting relapse … Read more

Does Ketamine Live Up to the Hype in Depression?

This transcript has been edited for clarity. Stephen M. Strakowski, MD: Hello. Thank you so much for joining us today. I’m very excited to have two very illustrious and intelligent guests talk us through an interesting topic, the use of ketamine for depression. I’m Dr Stephen Strakowski, a professor of psychiatry at both Indiana University … Read more

ECT Tied to Reduction in All-Cause Mortality in Major Depression

Electroconvulsive therapy (ECT) may lower mortality for patients with treatment-resistant major depressive disorder (MDD), new research suggests. In an analysis of data from a large database of inpatients across the United States, use of ECT for those with resistant MDD was associated with significantly lower in-hospital mortality compared with those who did not receive ECT. … Read more

New Data Support Electroconvulsive Therapy for Depression

Advocates and users of electroconvulsive therapy (ECT) have received further scientific backing: a retrospective cohort study has provided further evidence that ECT can prevent suicide among severely depressed patients. The patient cohort comprised 27,231 men and 40,096 women who had been treated as inpatients. The average age was 45.1 years (range: 18-103 years), and 4982 … Read more

The Role of Transcranial Magnetic Stimulation in Major Depressive Disorder

This transcript has been edited for clarity. Madhukar Trivedi, MD: Hello. Welcome to the podcast. My name is Madhukar Trivedi. I’m professor of psychiatry at UT Southwestern and the founding director of the Center for Depression Research and Clinical Care. Today it gives me great pleasure to introduce my colleague and friend, Dr Jonathan Downar, … Read more

A Little-Known Option for Depression

Standard therapies for depression are antidepressants and psychotherapy. In particularly severe cases, electroconvulsive therapy (ECT) or vagus nerve stimulation (VNS) may also be indicated. VNS is an approved, effective, well-tolerated, long-term therapy for chronic and therapy-resistant depression, write Christine Reif-Leonhardt, MD, and her team of researchers from the University Hospital Frankfurt am Main, Germany, in … Read more