Major Life Stressors ‘Strongly Predictive’ of Long COVID Symptoms

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. After recovery from acute infection with SARS-CoV-2, major stressful life events such as the death of a loved one or financial insecurity can have a significant impact on the development of long COVID symptoms, new research suggests. Major life stressors in … Read more

Brain Imaging Validates Cognitive Problems After Lyme Disease

New imaging data show distinctive brain changes that appear to explain memory and cognitive problems following Lyme disease. Using fMRI and diffusion tensor imaging (DTI) techniques, investigators found changes in white matter and other brain tissues in patients with posttreatment Lyme disease (PTLD) in comparison with healthy control persons who did not have a history … Read more

Single Dose of Psilocybin for Major Depression Tied to Short-Term Remission

A single 25 mg dose of synthetic psilocybin in combination with psychotherapy appears to effectively ease symptoms of treatment-resistant depression (TRD) — at least in the short-term, new research shows. In the largest study of psilocybin for TRD to-date, results of the phase 2b randomized, double-blind trial show participants in the 25-mg dose group experienced … Read more

Ketamine Promising for Rare Condition Linked to Autism

Ketamine may be an effective treatment for children with activity-dependent neuroprotective protein (ADNP) syndrome, a rare genetic condition associated with intellectual disability and autism spectrum disorder. Also known as Helsmoortel–Van Der Aa syndrome, ADNP syndrome is caused by mutations in the ADNP gene. Studies in animal models suggest that low-dose ketamine increases expression of ADNP … Read more

Yoga, CBT Provide Long-Term Improvement in Insomnia, Worry

Both yoga and cognitive behavioral therapy (CBT) provide meaningful improvements in worry, anxiety, and insomnia in older adults that last even 6 months after discontinuing treatment, new research suggests. The study is the first to compare the long-term effects from the two interventions; And the results offer clinicians and patients two effective choices for researchers … Read more

Inhaled, Systemic Steroids Linked to Changes in Brain Structure

New research links the use of glucocorticoids with changes in white matter microstructure — which may explain the development of anxiety, depression, and other neuropsychiatric side effects related to these drugs, investigators say. Results from a cross-sectional study showed that use of both systemic and inhaled glucocorticoids was associated with widespread reductions in fractional anisotropy … Read more

Sleep Loss Linked to Reduced Generosity, Even at a Neuronal Level

Sleep loss, ranging from the individual level of missing a night’s sleep to a societal level of losing an hour’s sleep because of Daylight Saving Time, is associated with reduced altruism or an inclination to help others, new research suggests. These effects were observed even at the neurologic level on brain MRIs, investigators report. “In … Read more

Simple Screening Tool Assesses Cognitive Impairment Post-COVID

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The covered study in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaway Patients with post-COVID syndrome have a long-term cognitive impairment that can last for more than 3 months and can … Read more

Most COVID Long-Haulers Suffer Fallout for More Than a Year

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Most COVID-19 long-haulers continue to have brain fog, fatigue and compromised quality of life more than a year after the initial infection, results from the most extensive follow up to date of a group of long COVID patients show. Most patients … Read more

The Anxious Patient Needs Psychosomatic Primary Care

A balance between fear and relaxation is normal. However, mental dispositions and the continuous influence of environmental stimuli can disrupt this balance. A failure in therapy can often conceal unvoiced fears. This article is based on the lecture “State of the Art: Treating Anxiety Disorders” by Christian Albus, MD, director of the Clinic and Polyclinic … Read more