Best Strategy to Prevent Schizophrenia Relapse Identified?

A large meta-analysis sheds light on the best antipsychotic maintenance strategy to prevent relapse in clinically-stable schizophrenia — with some unexpected results that have potential implications for changes to current guidelines. Consistent with the researchers’ hypothesis, continuing antipsychotic treatment at the standard dose, switching to another antipsychotic, and reducing the dose were all significantly more … Read more

Early Metformin Minimizes Antipsychotic-Induced Weight Gain

MAR DEL PLATA, Argentina ― Psychiatrists should prescribe metformin early to patients who experience rapid weight gain after they begin taking antipsychotic drugs, according to a new evidence-based Irish guideline for the management of this common complication in adults with psychoses who are taking medications. The document was discussed during one of the sessions of … Read more

How to Manage Drug Interactions With Paxlovid for COVID

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Misinformation about nirmatrelvir/ritonavir (PaxlovidPfizer) for treating mild-to-moderate COVID-19 in patients at high risk for severe disease is feeding misunderstanding among prescribers and patients, two experts from the Infectious Diseases Society of America (IDSA) said on Friday. They briefed reporters on potential … Read more

Study Provides New Data on Isotretinoin and Psychiatric Effects

The use of isotretinoin to treat acne was not associated with an increase in adverse neuropsychiatric outcomes, compared with the use of oral antibiotics, in a large retrospective cohort study published in the British Journal of Dermatology. Although severe neuropsychiatric effects associated with isotretinoin therapy in patients with acne have been reported, “the evidence base…is … Read more

One in Three Ukrainian Refugees Could Develop PTSD

According to estimates by the United Nations High Commissioner for Refugees (UNHCR), more than 3 million people have already fled from Ukraine. As of March 18, around 200,000 of these refugees had fled to Germany, according to information from that country’s police force. They are escaping from bombs, tanks, and the destroyed infrastructure of their … Read more

First Guidelines for Managing Anorexia in Pregnancy

The first comprehensive guidelines to manage pregnant women with anorexia nervosa (AN) have been released. Pregnant women with AN are at greater risk of poor outcomes including stillbirth, underweight infant, or pre-term birth, yet there are no clear guidelines on the management of the condition. “Anorexia in pregnancy has been overlooked area of ​​clinical care … Read more

Nursing Board Discriminates Against Those Seeking Opioid Help: DOJ

The US Department of Justice (DOJ) says the Indiana State Nursing Board discriminates against nurses with opioid use disorder (OUD), according to findings of a recently released investigation. Specifically, the board “violated the Americans with Disabilities Act (ADA) by prohibiting nurses who take medication to treat OUD from participating in the Indiana State Nursing Assistance … Read more

New Tool Cuts CVD Risk in Patients With Serious Mental Illness

A clinical decision support (CDS) system that can be implemented in primary care reduces cardiovascular risk factors (CV) common in patients with serious mental illness (SMI), new research suggests. Investigators assessed more than 70 primary care clinics that treated close to 9000 patients with SMI. Disorders included schizophrenia, bipolar disorder, and schizoaffective disorder. The clinics … Read more

DSM-5 Update: What’s New?

Ahead of its official release on March 18, the new Diagnostic and Statistical Manual of Mental Disorderswhich is in the form of a textbook, is already drawing some criticism. The American Psychiatric Association’s (APA) Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), which is not a full revision, only includes one … Read more