Psilocybin Effective Up to 12 Weeks in Severe Depression

NEW ORLEANS – A single dose of a synthetic formulation of psilocybin provides rapid improvement in treatment-resistant depression, with benefits sustained for up to 12 weeks, according to results from the largest randomized controlled study of psilocybin to date. Dr Guy Goodwin “This is easily the largest study of a psychedelic drug employing modern randomized … Read more

New Insight Into How Psychedelics Work

What causes the dramatic alterations in subjective awareness experienced during a psychedelic “trip?” A new study maps anatomical changes in specific neurotransmitter responsible systems and brain regions that may be for these effects. Investigators gathered over 6800 accounts from individuals who had taken one of 27 different psychedelic compounds. Using a machine learning strategy, they … Read more

Psilocybin ‘Rewires’ the Brain to Alleviate Depression

New research points to a general mechanism that may explain how psychedelics act on the brain to alleviate depression and potentially other psychiatric conditions marked by fixed patterns of thinking, including rumination and excessive self-focus. Led by investigators from the University of California San Francisco and Imperial College London’s Center for Psychedelic Research, the findings … Read more

Microdosing Psychedelics: Untapped Potential in Psychiatry?

In her month-long memoir, A Really Good Day: How Microdosing Made a Mega Difference in My Mood, My Marriage, and My Life (Knopf, 2017), author Ayelet Waldman turns herself into a one-woman experiment. Over a single month she takes one tenth of a recreational dose of LSD every third day. She plots her emotions, her … Read more

Psychedelics’ Interaction With Psych Meds: More Q’s Than A’s

Psychedelics, including psilocybin and MDMA, are promising for a variety of psychiatric disorders, but there are few data showing how these drugs interact with traditional psychiatric medications, new research shows. “Despite prolific psychedelic research and public interest, I was surprised to see little clinical research on how psilocybin and common psychiatric treatments interact,” study investigator … Read more