Lipid Signature May Flag Schizophrenia

A specific lipid profile can identify patients with schizophrenia, possibly paving the way for the development of the first clinically useful diagnostic test for a severe psychiatric illness, new research suggests. Although such a test remains a long way off, the investigators said, the identification of the unique lipid signature is a critical first step. … Read more

Assessment in Primary Care Pediatrics

The assessment and diagnosis of bipolar disorder in youth has a complicated and controversial history. I recall from my child and adolescent fellowship training that there was a thinly veiled faculty argument about the diagnosis itself with strong opinions on each side. To revisit this quandary, I reviewed the most up-to-date literature and outlined a … Read more

Stress Tolerance Influences Suicide Risk and Can Be Modified

The study covered in this summary was published on ResearchSquare as a preprint and has not yet been peer reviewed. Key Takeaways In people with depression, the relationship between stressful life events and suicide risk is completely mediated by distress tolerance, defined as an individual’s actual or perceived ability to experience, accept, and persist in … Read more

Sleep Complaints in MDD Flag Risk for Other Psychiatric Disorders

Sleep complaints by patients with a major depressive episode (MDE) may be a red flag signaling a higher risk for developing other psychiatric disorders, new research suggests. Investigators studied 3-year incidence rates of psychiatric disorders in almost 3,000 patients experiencing an MDE. Results showed that having a history of difficulty falling asleep, early morning awakening, … Read more

Postconcussion Symptoms Tied to High Risk of Depression

Persistent postconcussion symptoms (PPCS) are tied to a significantly increased risk of developing subsequent depressive symptoms, new research shows. Results from a large meta-analysis that included 18 studies and more than 9,000 patients showed a fourfold higher risk of developing depressive symptoms in those with PPCS versus those without PPCS. “In this meta-analysis, experiencing PPCS … Read more

IV Ketamine Effective for Resistant Depression in Older Adults?

Dr Marie Anne Gebara The administration of IV ketamine over the course of 2 months can improve treatment resistant depression (TRD) and executive function in older adults, findings from a new pilot study suggest. Results showed nearly 50% of participants responded to ketamine and 25% achieved complete remission from TRD, as measured by scores on … Read more

Treatment-Resistant Depression Ups Risk for Comorbidities, Death

Treatment-resistant depression (TRD) is significantly linked to comorbid psychiatric conditions and a higher risk for mortality, and can take more than a year to be diagnosed, new research shows. In a population study of more than 145,000 patients, participants with TRD used outpatient resources and missed work at twice the rate as patients with treatment-responsive … Read more

Can a Mediterranean Diet Ease Depression in Young Men?

This transcript has been edited for clarity. Drew Ramsey, MD: Welcome back everyone. I’m Dr Drew Ramsey. I’m on the editorial board with Medscape Psychiatry and I’m an assistant clinical professor of psychiatry at Columbia University. We have a special guest today. I’m here with nutritionist Jessica Bayes, who’s at the University of Technology Sydney, … Read more

Colorado Voters Decriminalize Psychedelic Mushrooms

DENVER (AP) — Colorado voters have passed a ballot initiative to decriminalize psychedelic mushrooms for people 21 and older and to create state-regulated “healing centers” where participants can experience the drug under supervision. Colorado becomes the second state, after Oregon, to vote to establish a regulated system for substances like psilocybin and psilocin, the hallucinogens … Read more

Novel Intervention Relieves Depression in MS Patients

An internet-based cognitive-behavioral therapy (iCBT) program specifically designed for patients with multiple sclerosis (MS) significantly reduced depressive symptoms compared to usual treatment, new research shows. Participants in the randomized controlled trial who received iCBT either benefits alone or in combination with weekly emails from therapists reported that persisted up to a year after therapy. Although … Read more