Clozapine and Cancer Risk: New Data

Dr. Jari Tiihonen Long-term treatment with clozapine is associated with a small, but significant, risk of hematological malignancies in individuals with schizophrenia, new research shows. Investigators found long-term clozapine use of more than 5 years was linked to a 2.7-fold increased risk of hematological malignancies in a dose-dependent manner compared with other antipsychotics. “Our results … Read more

High Suicide, Depression Risks for Patients With Cancer

Living with cancer can be emotionally devastating. Now, two expansive studies underscore the scale of the burden a cancer diagnosis and treatment can have on patients’ mental health and risk of suicide. In one, a meta-analysis of 28 studies that included more than 22 million patients, researchers found that among people with cancer, the suicide … Read more

J&J’s Janssen Settles With WVa for $99M in Opioid Lawsuit

CHARLESTON, W.Va. (AP) — West Virginia will receive $99 million in a settlement finalized Monday with Johnson & Johnson’s subsidiary Janssen Pharmaceuticals Inc. over the drugmaker’s role in perpetuating the opioid crisis in the state that has long led the nation in drug overdose deaths. State Attorney General Patrick Morrisey said during a news briefing … Read more

Top Drug Official Wants New Approach to Abuse Crisis

When a chemical spill left 300,000 West Virginians in need of clean drinking water and a public official they could trust, Rahul Gupta, MD, MPH, was there. When the March of Dimes needed a voice to fight legislation that threatened to gut healthcare for pregnant women, Gupta was front and center. Dr Rahul Gupta, MD … Read more

New Data Focus Need for Tailored Schizophrenia Care in Elderly

Older adults with schizophrenia are not a homogenous patient population, with various subgroups that differ significantly in terms of comorbid illness and mortality rates and causes, new research shows. For example, individuals in a group characterized by substance use disorders (SUDs) had a depression prevalence of about 60% and relatively high death rates from unintentional … Read more

From COVID to Ukraine, Fighting Crisis Fatigue

In casual conversation these days, you’re likely to hear: “I’m just done with COVID.” The problem is the virus isn’t done with us, yet. Nor is Ukraine inflation, or nuclear threats, to name a few. The statistics 2 years into the pandemic are sobering, or should be. Deaths from COVID-19 in the United States are … Read more

Suicide Attempts Now ‘Huge Problem’ Among Preteens

Suicide attempts spurring calls to poison control centers more than quadrupled among US children aged 10–12 years from 2000–2020, according to research published today in JAMA Pediatrics. For all children older than age 9, the proportion of suicide attempts increased as misuse or abuse of potentially poisonous substances declined. Only very young children (aged 6–9) … Read more