Sleep Abnormalities Common In All Stages of Psychosis

Sleep disturbances are consistently high throughout the course of psychosis — with later stages associated with distinctive brain wave activity during sleep, a new review and meta-analysis shows. For example, compared with their healthy peers, participants in a chronic psychosis stage had reduced density, amplitude, and duration of spindles — or bursts of brainwave activity … Read more

Postconcussion Symptoms Tied to High Risk of Depression

Persistent postconcussion symptoms (PPCS) are tied to a significantly increased risk of developing subsequent depressive symptoms, new research shows. Results from a large meta-analysis that included 18 studies and more than 9,000 patients showed a fourfold higher risk of developing depressive symptoms in those with PPCS versus those without PPCS. “In this meta-analysis, experiencing PPCS … Read more

ADHD Meds and Cardiovascular Safety: New Data

A new study provides some reassurance regarding the cardiovascular safety of medications used to treat attention-deficit/hyperactivity disorder (ADHD). A large meta-analysis showed no statistically significant association between use of stimulant or nonstimulant ADHD medications and any cardiovascular disease (CVD) outcome across age groups. However, a “modest” increase in risk could not be ruled out, especially … Read more

Recommending Exercise for Migraine: Just Do It

Strength training is the most effective form of exercise for reducing migraine, with high-intensity aerobics coming in second, and both beating top-line migraine medications topiramate and amitriptyline, new research suggests. The new results should encourage clinicians to recommend patients with migraine engage in strength-training exercise whenever possible, study author Yohannes W. Woldeamanuel, MD, a physician-scientist … Read more

1 in 7 Mortality Postsurgery; ECT and MDE; and Monkeypox News

One in Seven Older Adults Die Within 1 Year After Surgery One in seven older adults die within 1 year of major surgery. The risk for mortality is higher among people older than 80 years or who are frail or may have dementia, according to a new study of community-living individuals. The study did not … Read more

ECT Tops Ketamine for Major Depression

Electroconvulsive therapy (ECT) is more effective than intravenous (IV) ketamine for patients experiencing a major depressive episode (MDE) in new findings that are in line with the KetECT study ― the first head-to-head trial of ketamine and ECT. As reported by Medscape Medical News, the KetECT trial was published earlier this year. It showed that … Read more

‘U-Shaped’ Relationship Between Bipolar Risk and Parental Age

VIENNA — Individuals born to younger or older parents are at increased risk of developing bipolar disorder, new research suggests. Results from a meta-analysis of more than 210,000 patients with bipolar disorder and over 13 million healthy individuals showed that children of mothers younger than 20 years had a 23% increased risk for bipolar disorder … Read more

E-Health Program Improves Perinatal Depression

Patients with perinatal depression who used a specialized online tool showed improvement in symptoms, compared with controls who received routine care, based on data from 191 individuals. Although perinatal depression affects approximately 17% of pregnant women and 13% of postpartum women, the condition is often underrecognized and undertreated, Brian Danaher, PhD, of Influents Innovations, Eugene, … Read more

Deep Brain Stimulation Effective for OCD, but Barriers Persist

Deep brain stimulation (DBS) is safe and effective for individuals with severe obsessive-compulsive disorder (OCD) that has been resistant to conventional therapy, a meta-analytic review confirms. “DBS is a viable option for treatment-resistant OCD that can be expected to produce a significant clinical benefit in about 2 out of 3 cases,” study investigator Wayne Goodman, … Read more

MDD Tied to Childhood Trauma Is Treatable

Despite a higher symptom burden, patients with major depressive disorder (MDD) and a history of childhood trauma (CT) can achieve significant recovery following treatment with a combination of pharmacotherapy and psychotherapy, new research suggests. Results from a meta-analysis of 29 studies from 1966 to 2019, which included almost 7000 adults with MDD, showed that more … Read more