Deep Brain Stimulation Effective for OCD, but Barriers Persist

Deep brain stimulation (DBS) is safe and effective for individuals with severe obsessive-compulsive disorder (OCD) that has been resistant to conventional therapy, a meta-analytic review confirms. “DBS is a viable option for treatment-resistant OCD that can be expected to produce a significant clinical benefit in about 2 out of 3 cases,” study investigator Wayne Goodman, … Read more

MDD Tied to Childhood Trauma Is Treatable

Despite a higher symptom burden, patients with major depressive disorder (MDD) and a history of childhood trauma (CT) can achieve significant recovery following treatment with a combination of pharmacotherapy and psychotherapy, new research suggests. Results from a meta-analysis of 29 studies from 1966 to 2019, which included almost 7000 adults with MDD, showed that more … Read more

Questionnaire a First Step to Find Developmental Delays

The commonly used but sometimes debated Ages and Stages Questionnaire (ASQ), has modest utility for identifying developmental delays in young children, an Australian review and meta-analysis found. On this easily administered parent-completed screening tool, scores of more than 2 standard deviations below the mean in more than one of five domains had moderate sensitivity and … Read more

Best Strategy to Prevent Schizophrenia Relapse Identified?

A large meta-analysis sheds light on the best antipsychotic maintenance strategy to prevent relapse in clinically-stable schizophrenia — with some unexpected results that have potential implications for changes to current guidelines. Consistent with the researchers’ hypothesis, continuing antipsychotic treatment at the standard dose, switching to another antipsychotic, and reducing the dose were all significantly more … Read more

Sleep a Potential Treatment Target for Schizophrenia?

A new analysis reveals a bidirectional relationship between sleep patterns and schizophrenia, leading researchers to suggest that sleep may be a potential treatment target for the disorder. Applying a Mendelian randomization (MR) approach, the investigators selected genetic variants from a meta-analysis of genome-wide association studies (GWAS) conducted using data from UK Biobank and 23andMe. They … Read more

tDCS for Patients With Disorders of Consciousness

The study covered in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Meta-analysis data from eight randomized controlled trials (RCT) showed that transcranial direct-current stimulation (tDCS) treatment for patients with disorders of consciousness (DoC) was more effective at improving behavior performance compared to controls. Patients … Read more

Cannabinoids in Medicine: Limitless Hope or Hype?

What is the role of cannabinoids as an intoxicant and in medical applications today? This was the question addressed by Dieter Braus, MD, psychiatrist and neurologist at Vitos Clinic Rheingau in Eltville, Germany, at the DGIM Congress 2022. Dampening the Dopamine System Regardless of the type of substance-dependent addiction — whether alcohol, opiates, nicotine, or … Read more

Running to the Top: Exercise and Mental Health

An apple a day keeps the doctor away! We’ve probably been given this advice or know of others who have been given this advice time and time again… to eat healthier, and more important, to exercise. While exercise is not necessarily the cure-all for the world’s infections and diseases, it plays an important role in … Read more

Burnout ‘Highly Prevalent’ in Psychiatrists Across the Globe

Burnout in psychiatrists is “highly prevalent” across the globe, new research shows. In a review and meta-analysis of 36 studies and more than 5000 psychiatrists in European countries, as well as the United States, Australia, New Zealand, India, Turkey, and Thailand, results showed that 25% of respondents met criteria for burnout, as measured by the … Read more

Does Metformin Blunt Diabetes Link to Brain Aging?

Researchers published the study covered in this summary on medRxiv.org as a preprint that has not yet been reviewed. Key Takeaways Type 2 diabetes appears to significantly accelerate normal brain aging. Metformin use does not appear to prevent neurocognitive decline. Why This Matters Although preliminary evidence links type 2 diabetes to neurologic and cognitive decline, … Read more