Anorexia Linked to Notable Shrinkage of Key Brain Structures

Patients with anorexia nervosa (AN) have not able shrinkage in key brain structures and these deficits are less severe in patients on the path to weight recovery, a new brain imaging study shows. The reductions of cortical thickness, subcortical volumes, and cortical surface area were “very pronounced in acutely underweight anorexia,” Stefan Ehrlich, MD, PhD, … Read more

MRI Plus Deep Learning Models Estimate Brain-Aging

The covered study in this summary was published in bioRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Using the Layer-wise Relevance Propagation algorithm and various structural MRI modalities (T1-weighted, fluid-attenuated inversion recovery [FLAIR]and susceptibility-weighted magnitude images [SWI]), brain age can be estimated. The structural abnormalities found were changes in the … Read more

The Psychopathic Brain: New Insight

Structural brain differences appear to distinguish psychopaths from individuals without psychopathic traits, new research shows. Using MRI, researchers found that the striatum was about 10% larger on average in adults with psychopathic traits than in matched control persons and that this relationship was mediated by stimulation seeking and impulse. The striatum is a subcortical region … Read more

Abnormal Growth of the Amygdala in Infants Tied to Autism

A new study suggests that overgrowth of the amygdala in infants during the first 6 to 12 months of life is tied to a later diagnosis of autism spectrum disorder (ASD). “The faster the amygdala grew in infancy, the more social difficulties the child showed when diagnosed with autism a year later,” first author Mark … Read more

‘Pandemic Brain’ Not Limited to Patients Infected With COVID-19

The stress of living through a pandemic may cause brain inflammation even in those uninfected with SARS-CoV-2, a new study suggests. Healthy individuals who tested negative for the virus that causes COVID-19 had elevated levels of inflammatory markers known to be involved in depression, stress, and mental fatigue. The study indicates a possible link between … Read more

First ‘Before-and-After’ COVID Brain Imaging Study Shows Changes

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Even mild cases of COVID-19 are associated with brain changes including decreased gray matter, an overall reduction in brain volume, and cognitive decline, a new imaging study shows. In the first study to use magnetic resonance brain imaging, before and after … Read more

CSF Inflammatory Markers Tied to Brain Alterations in SARS-CoV-2

The study covered in this summary was published in medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaway Cerebrospinal fluid (CSF) inflammatory marker levels were found to be associated with changes in gray matter volume and cortical thickness in the frontal, orbitofrontal, and temporal regions in hospitalized patients with severe SARS-CoV-2 … Read more