Antiepileptic Meds Tied to Increased Parkinson Risk

Antiepileptics are linked to an increased risk of Parkinson’s disease (PD), new research suggests. Drawing on data from the UK Biobank, investigators compared over 1,400 individuals diagnosed with PD to matched control persons and found a significantly higher risk of developing PD among those who had taken antiepileptic drugs (AEDs) in comparison with those who … Read more

Green, Blue Space Linked to Fewer Parkinson’s Hospitalizations

Exposure to natural environments may lower hospitalizations for patients with neurodegenerative disorders, new research suggests. In a large, open-cohort study, living in areas rich with greenery, parks, and waterways (blue space) was linked to fewer hospitalizations for Parkinson’s disease (PD); and residing near green spaces was associated with fewer hospitalizations for Alzheimer’s disease and related … Read more

High Neuro Drug Costs Exclude Most From Cutting-Edge Tx

Because of high out-of-pocket costs of new-to-market neurologic drugs that are of similar benefit as older agents, only a small percentage of patients with neurologic disorders have access to these cutting-edge medications, new research shows. “Our study of people with neurologic conditions found fewer than 20% were being treated with new medications,” study author Brian … Read more

Why We Shouldn’t Mess With Dopamine

Google the word “dopamine” and you will learn that its nicknames are the “happy hormone” and the “pleasure molecule” and that it is among the most important chemicals in our brains. With The Guardian Branding it “the Kim Kardashian of neurotransmitters,” dopamine has become a true pop-science darling — people across the globe have attempted … Read more

Acupuncture Eases Anxiety in Parkinson’s Patients

Acupuncture is an effective treatment for anxiety in patients with Parkinson’s disease (PD), results of a randomized controlled trial show. Both sham and real acupuncture eased PD-related anxiety at the end of 8-week treatment, but only real acupuncture had an enduring effect at 2 months after treatment ended. The early effect with sham acupuncture in … Read more

Baseline Neuromotor Abnormalities Persist in Schizophrenia

Baseline dyskinesia and neurological soft signs (NSS) predicted the disease process of schizophrenia over a 21-year follow-up period, based on data from 243 adult patients. Neuromotor abnormalities in psychotic disorders have long been ignored as side effects of antipsychotic drugs, but they are gaining new attention as a component of the disease process, with implications … Read more

Mortality Advantage With Pimavanserin in Parkinson’s Psychosis?

Pimavanserin may convey a mortality advantage over other treatments for older adults with Parkinson’s disease (PD) psychosis, new research suggests. In a real-world analysis of more than 21,000 patients with PD psychosis, treatment with pimavanserin was associated with significantly lower mortality compared with off-label use of atypical antipsychotics. However, this was only found during the … Read more

The Role of Transcranial Magnetic Stimulation in Major Depressive Disorder

This transcript has been edited for clarity. Madhukar Trivedi, MD: Hello. Welcome to the podcast. My name is Madhukar Trivedi. I’m professor of psychiatry at UT Southwestern and the founding director of the Center for Depression Research and Clinical Care. Today it gives me great pleasure to introduce my colleague and friend, Dr Jonathan Downar, … Read more

DBS Helpful for Motor Function but Not Depression in Parkinson’s

Treatment with deep brain stimulation improved motor function and quality of life, but depression scores increased after 1 year, based on data from 20 adults. Subthalamic nucleus deep brain stimulation (STN-DBS) has emerged as an effective treatment for Parkinson’s disease symptoms, with evidence supporting improved motor symptoms and quality of life, wrote Francesca Mameli, PsyD, … Read more

Restless Legs Syndrome Common in X-linked Adrenoleukodystrophy

Restless legs syndrome occurred in approximately 40% of adults with X-linked adrenoleukodystrophy, based on data from 32 individuals. Patients with X-linked adrenoleukodystrophy (ALD), a neurodegenerative disease, often experience gait and balance problems, as well as leg discomfort, sleep disturbances, and pain, wrote John W. Winkelman, MD, of Massachusetts General Hospital, Boston, and colleagues . Restless … Read more