Children With Mild TBI at Risk for Behavioral and Emotional Problems

The study covered in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Mild traumatic brain injury (mTBI) and possible mTBI are associated with greater risk for poor behavioral and mental health outcomes in adolescents. An unexpected finding was the association of mTBI with decreased cerebrospinal … Read more

Understanding the Neuroscience of Narcissism

The covered study in this summary was published on ResearchSquare.com as a preprint and has not yet been reviewed. Key Takeaway Maladaptive schemas (entitlement, vulnerability, and emotional deprivation) and cognitive evaluation systems (self-esteem and systemizing-empathizing) are associated with grandiose and vulnerable narcissism. Why This Matters The cognitive features and phenotypic diversity of narcissism subtypes are … Read more

MRI Plus Deep Learning Models Estimate Brain-Aging

The covered study in this summary was published in bioRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Using the Layer-wise Relevance Propagation algorithm and various structural MRI modalities (T1-weighted, fluid-attenuated inversion recovery [FLAIR]and susceptibility-weighted magnitude images [SWI]), brain age can be estimated. The structural abnormalities found were changes in the … Read more

Two Promising Bridge Therapies for Medication Overuse Headaches

This study was published as a preprint and has not yet been peer reviewed. Key Takeaway Among patients with MOH of longer duration, response to treatment was lower, highlighting the importance of early diagnosis and rapid treatment for these headaches. Why This Matters MOH affects 1% to 2% of the general population. It is a … Read more

Simple Screening Tool Assesses Cognitive Impairment Post-COVID

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The covered study in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaway Patients with post-COVID syndrome have a long-term cognitive impairment that can last for more than 3 months and can … Read more

Refugees’ High Burden of Chronic Pain Tied to Mental Illness

The covered study in this summary was published in researchsquare.com and has not yet been peer reviewed. Key Takeaways The study found a high burden of chronic pain in Syrian adults refugees in Norway that has adverse consequences towards their daily workers. Anxiety, depression, and PTSD are associated with higher levels of chronic pain in … Read more

Oxytocin and Social interaction Improves Symptoms in Autism

The study covered in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Novel reduced-dose intranasal oxytocin followed by a period of positive social interaction improved symptoms in young children with autism spectrum disorder (ASD). In the study, improvement was seen in objective and subjective measures, … Read more

Neurocognitive Sequelae of COVID-19 After Acute Infection

The study covered in this summary was published in medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways The burden of self-reported post-acute symptoms and possible sequelae, particularly fatigue and neurocognitive impairment, remains significant 6 to 12 months after acute, even among young and middle-aged adults after mild acute SARS-CoV-2 infection, … Read more

Placebo Response in Neuropathic Pain Trials

The study covered in this summary was published in medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Both placebo and nocebo effects can greatly affect the interpretation of outcomes in randomized controlled trials of chronic neuropathic pain treatments. When trials are being designed and interpreted, these effects need to be … Read more

CSF Inflammatory Markers Tied to Brain Alterations in SARS-CoV-2

The study covered in this summary was published in medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaway Cerebrospinal fluid (CSF) inflammatory marker levels were found to be associated with changes in gray matter volume and cortical thickness in the frontal, orbitofrontal, and temporal regions in hospitalized patients with severe SARS-CoV-2 … Read more