Naloxone May Fail for Overdoses Tainted With ‘Tranq,’ FDA Warns

The US Food and Drug Administration (FDA) is alerting healthcare professionals about the special management required for opioid overdoses tainted with xylazine, an animal tranquilizer known on the street as tranq, tranq dope, sleep-cut, Philly dope, and zombie drug. The tranquilizer is often combined with fentanyl or heroin, or occasionally with a stimulant, said the … Read more

Antibiotic May Enhance TMS, Improve Depression Outcomes

Administering D-cycloserine (DCS) along with transmagnetic stimulation (TMS) may be a promising strategy to improve outcomes in major depressive disorder (MDD), new research suggests. “The take-home message is that this proof-of-concept study opens up a new avenue of treatment research so that in the future, we may be able to provide our patients with safe … Read more

No Evidence Low Serotonin Causes Depression?

There is no convincing evidence that low serotonin levels are the primary cause of depression. This is the conclusion of an “exhaustive” review by UK investigators, which upends the widely held belief that depression is the result of lower levels, or reduced activity, of the chemical. Researchers say the results call antidepressant use into question. … Read more

New Insight Into How Psychedelics Work

What causes the dramatic alterations in subjective awareness experienced during a psychedelic “trip?” A new study maps anatomical changes in specific neurotransmitter responsible systems and brain regions that may be for these effects. Investigators gathered over 6800 accounts from individuals who had taken one of 27 different psychedelic compounds. Using a machine learning strategy, they … Read more

CBD May Help People Cut Down on Their Cannabis Use

PARIS — Following the suspension of the decree that banned the sale of cannabidiol (CBD) flowers, raw cannabis is again available in France for over-the-counter sales. The “feel-good” plant is praised for its relaxing properties. The suspension of the ban, which lasted for 3 weeks, is a mixed blessing for businesses that sell CBD-based products … Read more