Lower-Dose Antipsychotics Benefit Patients with Schizophrenia

NEW ORLEANS — Patients with treatment-refractory schizophrenia in a long-term forensic facility showed significant stability following reduced doses of long-acting injectable antipsychotics, a study revealed. Dr Mujeeb Shad “There is an argument by some experts in the field that state hospital populations represent a different set of patients who require higher antipsychotic dosages, with no … Read more

Social Activities May Offset Psychosis Risk in Poor Communities

Social engagement such as participation in community or school-based activities may mitigate psychosis risk in susceptible youth living in disadvantaged communities, new research suggests. A study of more than 170 young participants showed reduced hippocampal volume in those living in poor neighborhoods who had low social engagement vs their peers with greater community engagement. Dr. … Read more

High-Dose Antipsychotics Effective in Refractory Schizophrenia

NEW ORLEANS – Patients with severe schizophrenia who fail to respond to treatment with standard doses of second-generation antipsychotics show significant improvement with – and tolerance of – higher maintenance doses of the drugs, new research shows. Dr Juan Jose Fernandez-Miranda The use of [higher doses of] long-acting injectable second-generation antipsychotics shows improvement not only … Read more

Antipsychotic Tied to Weight Gain, Higher Cholesterol

Increases in use of the antipsychotic risperidone (Risperdal) are associated with small dose-related increases in both weight and blood cholesterol levels, new research suggests. Investigators analyzed 1-year data for more than 400 patients who were taking risperidone and/or its metabolite paliperidone (Invega). Results showed increments of 1 mg of risperidone-equivalent doses were associated with an … Read more

Early Metformin Minimizes Antipsychotic-Induced Weight Gain

MAR DEL PLATA, Argentina ― Psychiatrists should prescribe metformin early to patients who experience rapid weight gain after they begin taking antipsychotic drugs, according to a new evidence-based Irish guideline for the management of this common complication in adults with psychoses who are taking medications. The document was discussed during one of the sessions of … Read more

When Does an Elite Athlete Need Mental Health Treatment?

MAR DEL PLATA, Argentina — Many athletes get the “jitters” — a feeling of anxiety — just prior to competing. For elite athletes, whether they’re participating in an individual event or as part of a team, whether on a track, court, rink, or field, this feeling can affect performance. It is a well-known, and not … Read more

Quick Pivot Upheld Schizophrenia Care During COVID

During the COVID-19 pandemic, mental health clinics in the United States successfully upheld the standard of care for patients with schizophrenia using telepsychiatry and long-acting injectable antipsychotics (LAIs), a new survey data show. “Mental health centers rose to the challenge and did what they needed to do for their patients,” study investigator Dawn Velligan, PhD, … Read more

Antipsychotic Safe, Effective for Resistant Depression

Cariprazine (Vraylar) is a safe and effective adjunctive treatment for adults with major depressive disorder (MDD) who have an inadequate response to antidepressant monotherapy, new results from a phase 3 study show. Already approved by the US Food and Drug Administration (FDA) to treat adults with schizophrenia and manic, mixed, or depressive episodes of bipolar … Read more

Multiple Mental Health Woes? Blame It on Genetics

Different psychiatric disorders often share the same architecture, which may help explain why many genetic individuals diagnosed with one psychiatric disorder will be diagnosed with another in their lifetime, new research suggests. Investigators conducted a genetic analysis of 11 major psychiatric disorders, including schizophrenia and bipolar disorder. “Our findings confirm that high comorbidity across some … Read more

New Data Support Electroconvulsive Therapy for Depression

Advocates and users of electroconvulsive therapy (ECT) have received further scientific backing: a retrospective cohort study has provided further evidence that ECT can prevent suicide among severely depressed patients. The patient cohort comprised 27,231 men and 40,096 women who had been treated as inpatients. The average age was 45.1 years (range: 18-103 years), and 4982 … Read more