US Ketamine Poisonings Up 81%

Ketamine poisonings in the United States increased 81% between 2019 and 2021, according to a new analysis of calls to poison control centers. Although the overall ketamine exposures were low, researchers say the findings add to a growing body of research that suggests recreational ketamine use may be on the rise. “Ketamine is by no … Read more

German ‘Island’ Aids Children and Adolescents With Addiction

They come from broken homes, from youth welfare organizations, or from the street. These are the addicted children and teenagers who seek help at Germany’s “Teen Spirit Island.” Medscape spoke to the pediatric and adolescent psychiatrist Frank M. Fischer, MD, senior physician of the Addiction and Trauma Therapy Ward at the Auf der Bult Children’s … Read more

Treatment-Resistant Depression Ups Risk for Comorbidities, Death

Treatment-resistant depression (TRD) is significantly linked to comorbid psychiatric conditions and a higher risk for mortality, and can take more than a year to be diagnosed, new research shows. In a population study of more than 145,000 patients, participants with TRD used outpatient resources and missed work at twice the rate as patients with treatment-responsive … Read more

Noninvasive Laser Therapy Tied to Improved Short-Term Memory

Transcranial photobiomodulation (tPBM), a noninvasive laser light therapy, can improve short-term memory in young adults when applied to the right prefrontal cortex (PFC) of the brain, new research suggests. Investigators compared the effect of 1064 nm of tPBM delivered over a 12-minute session to the right PFC vs three other treatment arms: delivery of the … Read more

Improving Sleep Boosts Cognition in Refractory Epilepsy

NASHVILLE, Tennessee ― Targeting relevant sleep problems for patients with refractory temporal lobe epilepsy (TLE) improves cognition, results of a new, double-blind, randomized controlled trial suggested. Study findings show significant improvement in REM sleep and language scores for patients with TLE who took the cholinesterase inhibitor donepezil and better slow-wave sleep and memory scores for … Read more

Brain Imaging Validates Cognitive Problems After Lyme Disease

New imaging data show distinctive brain changes that appear to explain memory and cognitive problems following Lyme disease. Using fMRI and diffusion tensor imaging (DTI) techniques, investigators found changes in white matter and other brain tissues in patients with posttreatment Lyme disease (PTLD) in comparison with healthy control persons who did not have a history … Read more

‘Amazing’ Phase 3 Results for Novel Schizophrenia Combo Drug

VIENNA — The investigational agent xanomeline-trospium (KarXT, Karuna Therapeutics) achieves significant and clinically meaningful improvements in schizophrenia symptom scores without causing problematic adverse effects, new research suggests. Results from the phase 3 EMERGENT-2 trial, which included more than 250 patients with schizophrenia, showed that those who received xanomeline-trospium for 5 weeks achieved a significant reduction … Read more

ECT Tops Ketamine for Major Depression

Electroconvulsive therapy (ECT) is more effective than intravenous (IV) ketamine for patients experiencing a major depressive episode (MDE) in new findings that are in line with the KetECT study ― the first head-to-head trial of ketamine and ECT. As reported by Medscape Medical News, the KetECT trial was published earlier this year. It showed that … Read more

Inhaled, Systemic Steroids Linked to Changes in Brain Structure

New research links the use of glucocorticoids with changes in white matter microstructure — which may explain the development of anxiety, depression, and other neuropsychiatric side effects related to these drugs, investigators say. Results from a cross-sectional study showed that use of both systemic and inhaled glucocorticoids was associated with widespread reductions in fractional anisotropy … Read more

Stable, Long-term Opioid Therapy Safer Than Tapering?

Discontinuing Stable, Long-TERM OPIOIID Therapy May Not BE NECESAY FOR PATIENTS who show no Signs of Misuse ― and IT COUL Even Be Safer Than Tapering Or Aburt Discontinism, New Research Suggests. Investigators Analyzed Data for Almost 200,000 Patients who did not have signs of OPIOOID USE DISEORDER (Oud) and Were Receiving Opioid Treatment. The … Read more