Sleep Abnormalities Common In All Stages of Psychosis

Sleep disturbances are consistently high throughout the course of psychosis — with later stages associated with distinctive brain wave activity during sleep, a new review and meta-analysis shows. For example, compared with their healthy peers, participants in a chronic psychosis stage had reduced density, amplitude, and duration of spindles — or bursts of brainwave activity … Read more

Sleep Complaints in MDD Flag Risk for Other Psychiatric Disorders

Sleep complaints by patients with a major depressive episode (MDE) may be a red flag signaling a higher risk for developing other psychiatric disorders, new research suggests. Investigators studied 3-year incidence rates of psychiatric disorders in almost 3,000 patients experiencing an MDE. Results showed that having a history of difficulty falling asleep, early morning awakening, … Read more

Treatment-Resistant Depression Ups Risk for Comorbidities, Death

Treatment-resistant depression (TRD) is significantly linked to comorbid psychiatric conditions and a higher risk for mortality, and can take more than a year to be diagnosed, new research shows. In a population study of more than 145,000 patients, participants with TRD used outpatient resources and missed work at twice the rate as patients with treatment-responsive … Read more

Improving Sleep Boosts Cognition in Refractory Epilepsy

NASHVILLE, Tennessee ― Targeting relevant sleep problems for patients with refractory temporal lobe epilepsy (TLE) improves cognition, results of a new, double-blind, randomized controlled trial suggested. Study findings show significant improvement in REM sleep and language scores for patients with TLE who took the cholinesterase inhibitor donepezil and better slow-wave sleep and memory scores for … Read more

More Evidence Insomnia Contributes to Cognitive Decline

A new study provides more evidence that insomnia may contribute to cognitive decline in older adults and shows that difficulty falling asleep in midlife may be most indicative of future cognitive impairment. Investigators found that having trouble falling asleep most nights (vs rarely/never) was equivalent to the effect of 2 to 3 years of aging … Read more

Major Life Stressors ‘Strongly Predictive’ of Long COVID Symptoms

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. After recovery from acute infection with SARS-CoV-2, major stressful life events such as the death of a loved one or financial insecurity can have a significant impact on the development of long COVID symptoms, new research suggests. Major life stressors in … Read more

Less Than 5 Hours of Sleep a Night Linked to Chronic Illness

Individuals who are middle-aged and older and who sleep 5 hours or less a night may be at risk for an array of serious and chronic health conditions, ranging from heart disease to cancer, results of a large study show. Researchers at University College London in the United Kingdom and Université Paris Cité, France, found … Read more

Wake-up Call on Sleep and Cardiovascular Health

Cardiovascular health (CVH) scores that include sleep predicted CV disease risk among older US adults, supporting the American Heart Association (AHA)’s recent inclusion of sleep in its own checklist. Sleep duration is now considered “an essential component for ideal heart and brain health,” according to the AHA’s updated checklist, now called Life’s Essential 8. “Our … Read more

Not Just a Bad Dream: Nightmares May Predict Dementia

Nightmares in healthy middle-aged and older adults may be an independent risk factor for cognitive decline and dementia, particularly in men, new research suggests. Results from a large cohort study showed that healthy middle-aged adults who had bad dreams at least once a week were four times more likely to experience cognitive decline over the … Read more

Timing of Food Intake a Strategy for Treating Mood Disorders?

Shift workers who confine their eating to the daytime may experience fewer mood symptoms compared to those who eat both day and night, new research suggests. Investigators at Brigham and Women’s Hospital, Boston, Massachusetts, created a simulated nightwork schedule for 19 individuals in a laboratory setting. Participants then engaged in two different meal timing models … Read more