First Known Opiate Biomarker Shows Fentanyl’s Effect on Brain

Fentanyl depresses breathing about 4 minutes before symptoms of distress are evident at a dose that is 1700 times lower than that needed for sedation, new research shows. This new information comes after researchers identified a unique EEG signature produced by fentanyl, the first known biomarker of an opiate’s effect on the brain. By monitoring … Read more

WPATH Removes Age Limits From Transgender Treatment Guidelines

Long-awaited global transgender care guidelines have dropped, with no recommendations regarding age limits for treatment and surgery in teenagers but acknowledging the complexity of dealing with such adolescents amid lack of longitudinal research on the impact of transitioning gender. The World Professional Association of Transgender Health (WPATH) published its latest standards of care (SOC) 8 … Read more

AHA Guidance on Infective Endocarditis With Injection Drug Use

Prompted by the “unprecedented” increase in the occurrence of infective endocarditis cases among people who inject drug, the American Heart Association (AHA) has issued a scientific statement devoted to this challenging patient population. The statement provides a more in-depth focus on the management of infective endocarditis (IE) among this unique population than what has been … Read more

They Call It ‘Tranq,’ and It’s Making Street Drugs More Dangerous

Approaching a van that distributes supplies for safer drug use in Greenfield, Massachusetts, a man named Kyle noticed an alert about xylazine. “Xylazine?” he asked, sounding out the unfamiliar word. “Tell me more.” Tapestry Health Systems nurse Katy Robbins hands bottles of water to Kyle as he visits the harm reduction mobile unit in Greenfield, … Read more

Detransitioners Lament Inadequate Clinical Support

Transgender people who medically detransition — those who stop or switch gender-affirming hormone therapy or who undergo a reversal of a surgical reconstruction — report feeling stigmatized by clinicians and receiving inadequate professional support, researchers have found. As a result, such patients often avoid healthcare at the time they stop undergoing medical interventions, and many … Read more

Postsurgical Opioid Refills Risky for Entire Household

Postsurgical opioid refills are associated with an increased risk for opioid misuse among family members — and the more refills, the higher the risk, new research suggests. Further results showed that if a surgical patient became a chronic opioid user, the likelihood of a family member misusing these drugs increased 2.5 times. “Patients requiring ongoing … Read more

Primary Hyperparathyroidism Raises Fracture, CV Risk

Dr Mattias Lorentzon Patients with untreated primary hyperparathyroidism show significant increases in the risk of hip fracture, cardiovascular events, and mortality, however, the risk is reduced when treated with parathyroidectomy, results from a large sample of patients in Sweden show. “Our results indicate that the risk of these severe outcomes is lower after surgery than … Read more

No More Autopilot Opioids After Cesarean Delivery

A group of clinicians is hoping to prompt a rethink of how opioids are prescribed to new mothers after cesarean deliveries after finding that sending patients home with smaller prescriptions led to dramatic drops in use of the drugs. In research scheduled to be presented Saturday at the 2022 annual meeting of the American College … Read more

the History and Future of Psychosurgery

In the early 20th century, there were a few psychiatrists ― perhaps intrepid, perhaps deluded ― who, despite no formal surgical training, were impelled to breach their patients’ skulls. Inspired by the surgical innovations of the day, they were curious about the physical nature of the psyche and whether invasive surgical procedures might be a … Read more

Shoulder Arthritis Surgery: Depression Complicates Care

Patients undergoing primary reverse shoulder arthroplasty (RSA) for their glenohumeral osteoarthritis (OA) had more complications of care and higher hospital costs when they also had a diagnosis of depression, new data show. The abstract was presented Thursday at the American Academy of Orthopedic Surgeons (AAOS) 2022 Annual Meeting. Researchers, led by Keith Diamond, MD, an … Read more