Stress Tolerance Influences Suicide Risk and Can Be Modified

The study covered in this summary was published on ResearchSquare as a preprint and has not yet been peer reviewed. Key Takeaways In people with depression, the relationship between stressful life events and suicide risk is completely mediated by distress tolerance, defined as an individual’s actual or perceived ability to experience, accept, and persist in … Read more

I Missed It: Coping With Medical Error

Thursday Night It was 9 o’clock at night when my phone rang. I didn’t recognize the number but decided to answer it anyway. It was my doctor. “Chase, I got your labs back and you have a critically low level. I spoke with someone at the hospital, I think I know what is happening, but … Read more

High-Dose Antipsychotics Effective in Refractory Schizophrenia

NEW ORLEANS – Patients with severe schizophrenia who fail to respond to treatment with standard doses of second-generation antipsychotics show significant improvement with – and tolerance of – higher maintenance doses of the drugs, new research shows. Dr Juan Jose Fernandez-Miranda The use of [higher doses of] long-acting injectable second-generation antipsychotics shows improvement not only … Read more

Novel Long-Acting Injection Cuts Schizophrenia Relapse

A long-acting subcutaneous antipsychotic (LASCA) suspension that combines risperidone with a novel copolymer substantially reduces both risk for relapse and time to impending relapse for patients with schizophrenia, new research suggests. In the phase 3 Risperidone Subcutaneous Extended-release (RISE) trial, which included more than 500 patients with schizophrenia, those who received the novel combination treatment, … Read more